McCarran Airport in Las Vegas offers some of the smoothest transitions from bags to ground transportation. Take the $7 shuttle to the strip if alone, but if 2 or more probably best to use a taxi for $14-$20 depending on your hotel location. Mandalay Bay, New York New York, Luxor, Excalibur, Tropicana, Hooters, MGM and more are at the McCarran end of the strip while Circus Circus and Stratosphere are at the North End. Wynn, Paris, Venetian, Bellagio, CityCenter (Mandarin Oriental, Vdara, Aria) are basically near the Center of the strip though you should always orient yourself with the strip before a trip to Vegas.
Walking is almost out of the question for distance (2+ miles to center strip) and security reasons (route is tricky, route is not really designed for walking safely, few other people around).